Article
Dopamine transporter gene variation modulates activation of striatum in youth with ADHD.
NeuroImage - 15 Nov 2010
Bédard Anne-Claude, Schulz Kurt P, Cook Edwin H, Fan Jin, Clerkin Suzanne M, Ivanov Iliyan, Halperin Jeffrey M, Newcorn Jeffrey H
Abstract excerpt
Polymorphisms in the 3'UTR variable number tandem repeat (VNTR) of exon 15 of the dopamine transporter gene (DAT1) have been linked to attention-deficit hyperactivity disorder (ADHD); moreover, variability in DAT1 3'UTR genotype may contribute to both heterogeneity of the ADHD phenotype and differences in response to stimulant medications. The impact of this VNTR on neuronal function in individuals with ADHD...
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