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Article

Post-aggregation oxidation of mutant huntingtin controls the interactions between aggregates.

The Journal of biological chemistry - 5 Oct 2012

Mitomi Yasushi, Nomura Takao, Kurosawa Masaru, Nukina Nobuyuki, Furukawa Yoshiaki

Abstract excerpt

Aggregation of protein molecules is a pathological hallmark of many neurodegenerative diseases. Abnormal modifications have often been observed in the aggregated proteins, supporting the aggregation mechanism regulated by post-translational modifications on proteins. Modifications are in general assumed to occur in soluble proteins before aggregation, but actually it remains quite obscure when proteins are...

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Identifiers

PMID: 22891249
DOI: 10.1074/jbc.M112.387035
PMCID: PMC3464579

Genes

HTT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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