Article
Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease.
FEBS letters - 27 Nov 1998
El-Agnaf O M, Jakes R, Curran M D, Wallace A
Abstract excerpt
Alpha-synuclein (alpha-syn) protein has been found in association with the pathological lesions of a number of neurodegenerative diseases. Recently, mutations in the alpha-syn gene have been reported in families susceptible to an inherited form of Parkinson's disease. We report here that human wi...
Topics
- Amino Acid Substitution
- Amyloid
- Benzothiazoles
- Biopolymers
- Circular Dichroism
- Dimerization
- Humans
- Hydrogen-Ion Concentration
- Lewy Bodies
- Microscopy, Electron
- Mutation
- Nerve Tissue Proteins
- Parkinson Disease
- Protein Structure, Secondary
- Recombinant Proteins
- Synucleins
- Thiazoles
- alpha-Synuclein