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Article

5‑FU resistance abrogates the amplified cytotoxic effects induced by inhibiting checkpoint kinase 1 in p53‑mutated colon cancer cells.

International journal of oncology - 1 Jan 2015

Akasaka Tomofumi, Tsujii Masahiko, Kondo Jumpei, Hayashi Yoshito, Ying Jin, Lu Yuquan, Kato Motohiko, Yamada Takuya, Yamamoto Shunsuke, Inoue Takuya, Tsujii Yoshiki, Maekawa Akira, Fujinaga Tetsuji, Shiraishi Eri, Hiyama Satoshi, Inoue Takahiro, Shinzaki Shinichiro, Watabe Kenji, Nishida Tsutomu, Iijima Hideki, Takehara Tetsuo

Abstract excerpt

The emergence of chemoresistance is a major limitation of current cancer therapies, and checkpoint kinase (Chk1) 1 positively correlates with resistance to chemo‑ or radio‑therapy. Cancer cells lacking p53 pathways are completely dependent on the S and G2/M checkpoints via Chk1; therefore, Chk1 inhibition enhances the cytotoxicity of DNA‑damaging agents only in p53‑deficient cells. However, little is known about...

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PMID: 25310623
DOI: 10.3892/ijo.2014.2693

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ATM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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