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Article

Curcumin causes superoxide anion production and p53-independent apoptosis in human colon cancer cells.

Cancer letters - 1 Nov 2010

Watson Jane L, Hill Richard, Yaffe Paul B, Greenshields Anna, Walsh Mark, Lee Patrick W, Giacomantonio Carman A, Hoskin David W

Abstract excerpt

Curcumin from the rhizome of theCurcuma longa plant has chemopreventative activity and inhibits the growth of neoplastic cells. Since p53 has been suggested to be important for anticancer activity by curcumin, we investigated curcumin-induced cytotoxicity in cultures of p53(+/+) and p53(-/-) HCT-116 colon cancer cells, as well as mutant p53 HT-29 colon cancer cells. Curcumin killed wild-type p53 HCT-116 cells and...

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Identifiers

PMID: 20472336
DOI: 10.1016/j.canlet.2010.04.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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