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Article

Long-lasting reduction in clonogenic potential of colorectal cancer cells by sequential treatments with 5-azanucleosides and topoisomerase inhibitors.

BMC cancer - 16 Nov 2016

Pawlak Alicja, Ziolo Ewa, Fiedorowicz Anna, Fidyt Klaudyna, Strzadala Leon, Kalas Wojciech

Abstract excerpt

BACKGROUND: The currently approved therapies fail in a substantial number of colorectal cancer (CRC) patients due to the molecular heterogeneity of CRC, hence new efficient drug combinations are urgently needed. Emerging data indicate that 5-azanucleosides are able to sensitize cancer cells to the standard chemotherapeutic agents and contribute to overcoming intrinsic or acquired chemoresistance. METHODS: CRC...

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PMID: 27852227
DOI: 10.1186/s12885-016-2925-6
PMCID: PMC5112712

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