Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Radiosensitization of colorectal carcinoma cell lines by histone deacetylase inhibition.

Radiation oncology (London, England) - 3 Aug 2006

Flatmark Kjersti, Nome Ragnhild V, Folkvord Sigurd, Bratland Ase, Rasmussen Heidi, Ellefsen Mali Strand, Fodstad Øystein, Ree Anne Hansen

Abstract excerpt

BACKGROUND: The tumor response to preoperative radiotherapy of locally advanced rectal cancer varies greatly, warranting the use of experimental models to assay the efficacy of molecular targeting agents in rectal cancer radiosensitization. Histone deacetylase (HDAC) inhibitors, agents that cause hyperacetylation of histone proteins and thereby remodeling of chromatin structure, may override cell cycle checkpoint...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle
Share to Chromatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, p53

Share to Histone Deacetylase Inhibitors

Share to Histone Deacetylases

Share to Histones

Share to Radiation-Sensitizing Agents

Share to Radiotherapy

Source

Open in PubMed Open full text

Identifiers

PMID: 16887021
DOI: 10.1186/1748-717X-1-25
PMCID: PMC1553456

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Radiosensitization of colorectal carcinoma cell lines by histone deacetylase inhibition.PMID 16887021Read ↗

Cell cycle checkpoint signaling involved in histone deacetylase inhibition and radiation-induced cell deathSemantic proximity Read ↗

Genome wide expression analysis of radiation-induced DNA damage responses in isogenic HCT116 p53+/+ and HCT116 p53-/- colorectal carcinoma cell lines.Semantic proximity Read ↗

Rectal cancer and importance of chemoradiation in the treatment.Semantic proximity Read ↗

Chromosomal instability portends superior response of rectal adenocarcinoma to chemoradiation therapySemantic proximity Read ↗

Transcriptional control at regulatory checkpoints by histone deacetylases: molecular connections between cancer and chromatin.Semantic proximity Read ↗

HDAC inhibitor, valproic acid, induces p53-dependent radiosensitization of colon cancer cells.Semantic proximity Read ↗

Coordination of DNA Synthesis and Histone Gene Expression During Normal Cell Cycle Progression and After DNA DamageSemantic proximity Read ↗

Regulation of DNA Damage Following Termination of Hedgehog (HH) Survival Signaling at the level of the GLI Genes in Human Colon CancerSemantic proximity Read ↗

Class I Histone Deacetylase Expression Has Independent Prognostic Impact in Human Colorectal Cancer: Specific Role of Class I Histone Deacetylases <i>In vitro</i> and <i>In vivo</i>Semantic proximity Read ↗

XPO1 Inhibition Enhances Radiation Response in Preclinical Models of Rectal CancerSemantic proximity Read ↗

The farnesyl transferase inhibitor RPR-130401 does not alter radiation susceptibility in human tumor cells with a K-Ras mutation in spite of large changes in ploidy and lamin B distribution.Semantic proximity Read ↗

Blocking Hedgehog Survival Signaling at the Level of the GLI Genes Induces DNA Damage and Extensive Cell Death in Human Colon Carcinoma CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.