Article
Metformin mitigates gastrointestinal radiotoxicity and radiosensitises P53 mutation colorectal tumours via optimising autophagy.
British journal of pharmacology - 1 Sept 2020
Chen Long, Liao Fengying, Jiang Zhongyong, Zhang Chi, Wang Ziwen, Luo Peng, Jiang Qingzhi, Wu Jie, Wang Qing, Luo Min, Li Xueru, Leng Yu, Ma Le, Shen Gufang, Chen Zelin, Wang Yu, Tan Xu, Gan Yibo, Liu Dengqun, Liu Yunsheng, Shi Chunmeng
Abstract excerpt
BACKGROUND AND PURPOSE: There is an urgent but unmet need for mitigating radiation-induced intestinal toxicity while radio sensitising tumours for abdominal radiotherapy. We aimed to investigate the effects of metformin on radiation-induced intestinal toxicity and radiosensitivity of colorectal tumours. EXPERIMENTAL APPROACH: Acute and chronic histological injuries of the intestine from mice were used to assess...
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