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Article

Unique sequence and lesional tropism of a new variant of neuropathogenic friend murine leukemia virus.

Virology - 7 Jul 1997

Takase-Yoden S, Watanabe R

Abstract excerpt

FrC6 murine leukemia virus (MuLV) is a replication-competent, neuropathogenic variant derived from Friend MuLV (F-MuLV) complex. The A8 virus (a molecular clone of the FrC6 virus) induced marked spongiform degeneration in the brain similar to the FrC6 virus, but only mild lesions were found in the spinal cord. In contrast, PVC211 virus, which is also a neuropathogenic F-MuLV variant, caused marked spongiform...

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PMID: 9217064
DOI: 10.1006/viro.1997.8619

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