Article
Cellular tropism and localization in the rodent nervous system of a neuropathogenic variant of Friend murine leukemia virus.
Laboratory investigation; a journal of technical methods and pathology - 1 Sept 1992
Hoffman P M, Cimino E F, Robbins D S, Broadwell R D, Powers J M, Ruscetti S K
Abstract excerpt
BACKGROUND: We studied PVC-211 murine leukemia virus (MuLV) (1), a neuropathogenic variant of Friend MuLV, to determine its cellular tropism and distribution in the nervous system of infected rats and the factors that affected disease expression. EXPERIMENTAL DESIGN: Rats from five different stra...
Topics
- Animals
- Blood-Brain Barrier
- Cells, Cultured
- DNA, Viral
- Endothelium, Vascular
- Friend murine leukemia virus
- Genetic Variation
- Leukemia, Experimental
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C3H
- Nervous System
- Neuroglia
- Rats
- Rats, Inbred F344
- Rats, Inbred Lew
- Rats, Inbred WF
- Rats, Sprague-Dawley