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Article

Senescence-Accelerated Mouse (SAM) as an Animal Model of Senile Dementia: Pharmacological, Neurochemical and Molecular Biological Approach

1 Jan 1998

Abstract excerpt

To elucidate the fundamental mechanism of age-related deficiencies of learning and to develop effective drugs for intervention in age-related diseases such as learning dysfunctions, pertinent animal models that have characteristics closely similar to human dysfunctions should be established. SAM (senescence-accelerated mouse) has been established as a murine model of the SAM strains, groups of related inbred...

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Identifiers

PMID: 9920195
DOI: 10.1254/jjp.78.399

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