Article
Genetic analysis of learning and memory deficits in senescence-accelerated mouse (SAM).
Physiology & behavior - 31 Mar 2005
Tomobe Koji, Isobe Masaharu, Okuma Yasunobu, Kitamura Kyogo, Oketani Yoneshiro, Nomura Yasuyuki
Abstract excerpt
Genetic analysis of learning and memory deficits (LMD) in senescence-accelerated mouse P8 (SAMP8) was performed by cross-mating SAMP8 and Japanese Fancy Mouse 1 (JF1). The incidence of LMD in the F2 generation showed a 3:1 segregation ratio of mice with LMD to normal mice, and the incidence of LMD in the backcross generation of the F1 to JF1 parental strain was in agreement with a 1:1 ratio of mice with LMD to...
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