Article
Senescence-Accelerated Mouse (SAM) strains have a spontaneous mutation in the Abcb1a gene.
Experimental animals - 1 Jul 2008
Zhang Guohong, Zhang Beiru, Fu Xiaoying, Tomozawa Hiroshi, Matsumoto Kiyoshi, Higuchi Keiichi, Mori Masayuki
Abstract excerpt
Senescence-Accelerated Mouse (SAM) strains are used as animal models for gerontological research. Here, we report that the SAMR1 strain, which shows a high sensitivity to toxicity of the parasiticide ivermectin, has a spontaneous retroviral insertional mutation in the ATP-binding cassette, sub-family B (MDR/TAP), member 1A (Abcb1a) gene. This mutation is identical to that found in Crl:CF1-Abcb1a mice, which are...
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