Article
Mutation in Sodium-Glucose Cotransporter 2 Results in Down-Regulation of Amyloid Beta (A4) Precursor-Like Protein 1 in Young Age, Which May Lead to Poor Memory Retention in Old Age.
International journal of molecular sciences - 4 Aug 2020
Unno Keiko, Takagi Yoshiichi, Konishi Tomokazu, Suzuki Mitsuhiro, Miyake Akiyuki, Kurotaki Takumi, Hase Tadashi, Meguro Shinichi, Shimada Atsuyoshi, Hasegawa-Ishii Sanae, Pervin Monira, Taguchi Kyoko, Nakamura Yoriyuki
Abstract excerpt
Senescence-accelerated mouse prone 10 (SAMP10) exhibits cerebral atrophy and depression-like behavior. A line of SAMP10 with spontaneous mutation in the Slc5a2 gene encoding the sodium-glucose cotransporter (SGLT) 2 was named SAMP10/TaSlc-Slc5a2slc (SAMP10-ΔSglt2) and was identified as a renal diabetes model. In contrast, a line of SAMP10 with no mutation in SGLT2 (SAMP10/TaIdrSlc, SAMP10(+)) was recently...
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