Article
Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus.
Proceedings of the National Academy of Sciences of the United States of America - 5 Jan 2010
Humrich Jens Y, Morbach Henner, Undeutsch Reinmar, Enghard Philipp, Rosenberger Stefan, Weigert Olivia, Kloke Lutz, Heimann Juliane, Gaber Timo, Brandenburg Susan, Scheffold Alexander, Huehn Jochen, Radbruch Andreas, Burmester Gerd-Rüdiger, Riemekasten Gabriela
Abstract excerpt
The origins and consequences of a regulatory T cell (Treg) disorder in systemic lupus erythematosus (SLE) are poorly understood. In the (NZBxNZW) F(1) mouse model of lupus, we found that CD4(+)Foxp3(+) Treg failed to maintain a competitive pool size in the peripheral lymphoid organs resulting in a progressive homeostatic imbalance of CD4(+)Foxp3(+) Treg and CD4(+)Foxp3(-) conventional T cells (Tcon). In addition,...
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