Article
MicroRNA-223 is a novel negative regulator of HSP90B1 in CLL.
BMC cancer - 8 Apr 2015
Rodríguez-Vicente Ana E, Quwaider Dalia, Benito Rocío, Misiewicz-Krzeminska Irena, Hernández-Sánchez María, de Coca Alfonso García, Fisac Rosa, Alonso José-María, Zato Carolina, de Paz Juan Francisco, García Juan Luis, Sarasquete Ma Eugenia, Hernández José Ángel, Corchado Juan M, González Marcos, Gutiérrez Norma C, Hernández-Rivas Jesús-María
Abstract excerpt
BACKGROUND: MicroRNAs are known to inhibit gene expression by binding to the 3'UTR of the target transcript. Downregulation of miR-223 has been recently reported to have prognostic significance in CLL. However, there is no evidence of the pathogenetic mechanism of this miRNA in CLL patients. METHODS: By applying next-generation sequencing techniques we have detected a common polymorphism (rs2307842), in 24% of...
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