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Article

Hepatitis B virus mutants with precore-region defects in two babies with fulminant hepatitis and their mothers positive for antibody to hepatitis B e antigen.

Pediatric research - 1 Jan 1991

Terazawa S, Kojima M, Yamanaka T, Yotsumoto S, Okamoto H, Tsuda F, Miyakawa Y, Mayumi M

Abstract excerpt

Clones of hepatitis B virus (HBV) DNA were propagated from sera of two babies who developed neonatal fulminant hepatitis B, as well as from sera of their mothers who carried HBV with antibody to hepatitis B e antigen, and the precore-region sequences were determined. A point mutation from guanine to adenine, converting codon 28 for tryptophan (TGG) to a stop codon (TAG), was detected in 18 of 20 HBV DNA clones...

Topics

Amino Acid Sequence
Base Sequence
Carrier State
DNA, Viral
Defective Viruses
Female
Hepatitis B
Hepatitis B Antibodies
Hepatitis B e Antigens
Hepatitis B virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Infant, Newborn

Male

Molecular Sequence Data

Mutation

Pregnancy

Pregnancy Complications, Infectious

Virulence

Source

Identifiers

PMID: 2000259
DOI: 10.1203/00006450-199101000-00002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2000259-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Hepatitis B virus mutants with precore-region defects in two babies with fulminant hepatitis and their mothers positive for antibody to hepatitis B e antigen.PMID 2000259Read ↗

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Association of hepatitis B viral precore mutations with fulminant hepatitis B in Japan.Semantic proximity Read ↗

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Detection of precore/core-mutant hepatitis B virus genome in patients with acute or fulminant hepatitis without serological markers for recent HBV infection.Semantic proximity Read ↗

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