Article
Can cytoplasmic nucleophosmin be detected by immunocytochemical staining of cell smears in acute myeloid leukemia?
Haematologica - 1 Apr 2010
Mattsson Göran, Turner Susan H, Cordell Jacqueline, Ferguson David J P, Schuh Anna, Grimwade Lizz F, Bench Anthony J, Weinberg Olga K, Marafioti Teresa, George Tracy I, Arber Daniel A, Erber Wendy N, Mason David Y
Abstract excerpt
Mutations in the C-terminal region of nucleophosmin in acute myeloid leukemia (AML) result in aberrant cytoplasmic nucleophosmin (cNPM) in leukemic blast cells which is detectable by immunocytochemistry in bone marrow trephine (BMT) biopsy sections. We tested whether cNPM is detectable by immunoc...
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