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Article

Is the association of "cup-like" nuclei with mutation of the NPM1 gene in acute myeloid leukemia clinically useful?

American journal of clinical pathology - 1 Oct 2010

Bennett John M, Pryor Jennifer, Laughlin Todd S, Rothberg Paul G, Burack W Richard

Abstract excerpt

Cup-like nuclear invaginations (NIs) in acute myeloid leukemia (AML) blasts have been associated with NPM1 mutations. Precision for enumeration of NI blasts has not been previously studied. Furthermore, the sensitivity and specificity for the morphologic prediction of NPM1 mutations have been variously reported. By using 66 AML specimens (17 with NPM1 mutations and 49 without), we found that interobserver...

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Source

Identifiers

PMID: 20855646
DOI: 10.1309/AJCPULO8SLW0RKJL

Genes

NPM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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