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Article

Functional alterations in protein kinase C beta II expression in melanoma.

Pigment cell & melanoma research - 1 Apr 2010

Voris John P, Sitailo Leonid A, Rahn Heidi R, Defnet Ann, Gerds Aaron T, Sprague Robert, Yadav Vipin, Caroline Le Poole I, Denning Mitchell F

Abstract excerpt

Protein kinase C (PKC) is a heterogeneous family of serine/threonine protein kinases that have different biological effects in normal and neoplastic melanocytes (MCs). To explore the mechanism behind their differential response to PKC activation, we analyzed the expression profile of all nine PKC isoforms in normal human MCs, HPV16 E6/E7 immortalized MCs, and a panel of melanoma cell lines. We found reduced...

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Identifiers

PMID: 20015121
DOI: 10.1111/j.1755-148X.2009.00664.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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