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Article

Protein kinase C inhibitors sensitize GNAQ mutant uveal melanoma cells to ionizing radiation.

Investigative ophthalmology & visual science - 7 Apr 2014

Cerne Jasmina Ziva, Hartig Sean Michael, Hamilton Mark Patrick, Chew Sue Anne, Mitsiades Nicholas, Poulaki Vassiliki, McGuire Sean Eric

Abstract excerpt

PURPOSE: Uveal melanoma (UM) tumors require large doses of radiation therapy (RT) to achieve tumor ablation, which frequently results in damage to adjacent normal tissues, leading to vision-threatening complications. Approximately 50% of UM patients present with activating somatic mutations in the gene encoding for G protein αq-subunit (GNAQ), which lead to constitutive activation of downstream pathways,...

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Share to Combined Modality Therapy
Share to GTP-Binding Protein alpha Subunits

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP-Binding Protein alpha Subunits, Gq-G11

Share to Melanoma

Share to Radiation, Ionizing

Share to Real-Time Polymerase Chain Reaction

Share to Uveal Melanoma

Share to Uveal Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 24595385
DOI: 10.1167/iovs.13-13468
PMCID: PMC3979518

Genes

GNAQ
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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