Article
Frequent MN1 Gene Mutations in Malignant Peripheral Nerve Sheath Tumor.
Anticancer research - 1 Nov 2020
Kinoshita Izumi, Yamada Yuichi, Kohashi Kenichi, Yamamoto Hidetaka, Iwasaki Takeshi, Ishihara Shin, Toda Y U, Ito Yoshihiro, Susuki Yousuke, Kawaguchi Kengo, Ichiki Toshio, Sato Yuki, Furue Masutaka, Nakashima Yasuharu, Oda Yoshinao
Abstract excerpt
BACKGROUND/AIM: Malignant peripheral nerve sheath tumor (MPNST) is a rare soft-tissue tumor, and its diagnosis is usually made histopathologically. The effectiveness of chemotherapy and radiotherapy has not been established. We elucidated prognostic factors, diagnostic markers, and therapeutic targets. MATERIALS AND METHODS: Cases of MPNST were studied using next-generation sequencing. A total of 24 tumor...
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