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Article

Low PiB PET retention in presence of pathologic CSF biomarkers in Arctic APP mutation carriers.

Neurology - 17 Jul 2012

Schöll Michael, Wall Anders, Thordardottir Steinunn, Ferreira Daniel, Bogdanovic Nenad, Långström Bengt, Almkvist Ove, Graff Caroline, Nordberg Agneta

Abstract excerpt

OBJECTIVE: To investigate the particular pathology of the Arctic APP (APParc) early-onset familial Alzheimer disease (eoFAD) mutation for the first time in vivo with PET in comparison with other eoFAD mutations and sporadic Alzheimer disease (sAD). METHODS: We examined 2 APParc mutation carriers together with 5 noncarrier siblings cross-sectionally with (11)C-labeled Pittsburgh compound B (PiB) and...

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Source

Identifiers

PMID: 22700814
DOI: 10.1212/WNL.0b013e31825fdf18

Genes

APP
PSEN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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