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Article

Ubiquitylation-dependent downregulation of Nck regulates its functional activity.

FEBS letters - 3 Nov 2014

Joseph Noah, Reicher Barak, David Ahuvit, Matalon Omri, Barda-Saad Mira

Abstract excerpt

The Nck adapter protein is involved in key cellular functions, such as actin polymerization and reorganization, serving as a molecular bridge between the surface complex essential for foreign antigen recognition, the T-cell antigen receptor (TCR), and the actin machinery. However, the mechanisms regulating Nck expression and functions are unknown. In this study, we revealed Nck negative regulation and...

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Identifiers

PMID: 25218436
DOI: 10.1016/j.febslet.2014.08.033

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