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Article

Error-prone translesion replication of damaged DNA suppresses skin carcinogenesis by controlling inflammatory hyperplasia.

Proceedings of the National Academy of Sciences of the United States of America - 22 Dec 2009

Tsaalbi-Shtylik Anastasia, Verspuy Johan W A, Jansen Jacob G, Rebel Heggert, Carlée Leone M, van der Valk Martin A, Jonkers Jos, de Gruijl Frank R, de Wind Niels

Abstract excerpt

The induction of skin cancer involves both mutagenic and proliferative responses of the epidermis to ultraviolet (UV) light. It is believed that tumor initiation requires the mutagenic replication of damaged DNA by translesion synthesis (TLS) pathways. The mechanistic basis for the induction of p...

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Identifiers

PMID: 20007784
DOI: 10.1073/pnas.0909507106
PMCID: PMC2799833

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20007784-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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