Article
DNA damage-induced mutation: tolerance via translesion synthesis.
Mutation research - 30 Jun 2000
Kunz B A, Straffon A F, Vonarx E J
Abstract excerpt
Translesion synthesis (TLS) appears to be required for most damage-induced mutagenesis in the yeast Saccharomyces cerevisiae, whether the damage arises from endogenous or exogenous sources. Thus, the production of such mutations seems to occur primarily as a consequence of the tolerance of DNA lesions rather than an error-prone repair mechanism. Tolerance via TLS in yeast involves proteins encoded by members of...
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