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Article

Reversing the aging stromal phenotype prevents carcinoma initiation.

Aging - 1 Apr 2011

Lewis Davina A, Travers Jeffrey B, Machado Christiane, Somani Ally-Khan, Spandau Dan F

Abstract excerpt

The accumulation of senescent stromal cells in aging tissue changes the local microenvironment from normal to a state similar to chronic inflammation. This inflammatory microenvironment can stimulate the proliferation of epithelial cells containing DNA mutations which can ultimately lead to cancer. Using geriatric skin as a model, we demonstrated that senescent fibroblasts also alter how epithelial keratinocytes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21515933
DOI: 10.18632/aging.100318
PMCID: PMC3117456

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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