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Replication Stress, DNA Damage, Inflammatory Cytokines and Innate Immune Response

9 Apr 2020

Abstract excerpt

Complete and accurate DNA replication is essential to genome stability maintenance during cellular division. However, cells are routinely challenged by endogenous as well as exogenous agents that threaten DNA stability. DNA breaks and the activation of the DNA damage response (DDR) arising from endogenous replication stress have been observed at pre- or early stages of oncogenesis and senescence. Proper detection...

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PMID: 32283785
DOI: 10.3390/genes11040409

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