Article
T cell receptor cross-reactivity between similar foreign and self peptides influences naive cell population size and autoimmunity.
Immunity - 20 Jan 2015
Nelson Ryan W, Beisang Daniel, Tubo Noah J, Dileepan Thamotharampillai, Wiesner Darin L, Nielsen Kirsten, Wüthrich Marcel, Klein Bruce S, Kotov Dmitri I, Spanier Justin A, Fife Brian T, Moon James J, Jenkins Marc K
Abstract excerpt
T cell receptor (TCR) cross-reactivity between major histocompatibility complex II (MHCII)-binding self and foreign peptides could influence the naive CD4(+) T cell repertoire and autoimmunity. We found that nonamer peptides that bind to the same MHCII molecule only need to share five amino acids to cross-react on the same TCR. This property was biologically relevant because systemic expression of a self peptide...
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