Article
Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma.
Disease models & mechanisms - 1 Jan 2000
Arnold Shanna A, Rivera Lee B, Miller Andrew F, Carbon Juliet G, Dineen Sean P, Xie Yang, Castrillon Diego H, Sage E Helene, Puolakkainen Pauli, Bradshaw Amy D, Brekken Rolf A
Abstract excerpt
Utilizing subcutaneous tumor models, we previously validated SPARC (secreted protein acidic and rich in cysteine) as a key component of the stromal response, where it regulated tumor size, angiogenesis and extracellular matrix deposition. In the present study, we demonstrate that pancreatic tumors grown orthotopically in Sparc-null (Sparc(-/-)) mice are more metastatic than tumors grown in wild-type (Sparc(+/+))...
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