Article
Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma.
Disease models & mechanisms - 1 Jan 2000
Arnold Shanna A, Rivera Lee B, Miller Andrew F, Carbon Juliet G, Dineen Sean P, Xie Yang, Castrillon Diego H, Sage E Helene, Puolakkainen Pauli, Bradshaw Amy D, Brekken Rolf A
Abstract excerpt
Utilizing subcutaneous tumor models, we previously validated SPARC (secreted protein acidic and rich in cysteine) as a key component of the stromal response, where it regulated tumor size, angiogenesis and extracellular matrix deposition. In the present study, we demonstrate that pancreatic tumor...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.