Article

SPARC, a matricellular protein that protects cancer from therapy

2014-01-01

Abstract excerpt

The matricellular protein SPARC (secreted protein acidic and rich in cysteine) is a master regulator of tissue stroma; it is expressed during tissue remodeling and repair and its impaired regulation has a role in fibrotic responses, in determining the composition of the tumor-associated stroma and, less expected, in regulating the immune response. The complexity of studying SPARC in cancer stems from its concomita...

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Identifiers and source

Literature Corpus work: dcb729aa-1174-5630-8a15-fc9fd0768057
DOI: 10.21954/ou.ro.0000ef1d

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