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Article

Selection and Counterselection of the rtI233V Adefovir Resistance Mutation during Antiviral Therapy

10 Dec 2009

Abstract excerpt

Recently, we reported on three patients with chronic hepatitis B virus (HBV) infection for whom adefovir (ADF) therapy virologically failed, most likely due to a preexisting rtI233V HBV polymerase mutation. Here, we describe two further patients with chronic HBV infection who were found to develop the rtI233V mutation after initiation of ADF therapy. These patients represent the first cases known so far in which...

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PMID: 20007398
DOI: 10.1128/jcm.01073-09

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