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Article

Resistance to adefovir dipivoxil therapy associated with the selection of a novel mutation in the HBV polymerase.

Gastroenterology - 1 Aug 2003

Angus Peter, Vaughan Rhys, Xiong Shelly, Yang Huiling, Delaney William, Gibbs Craig, Brosgart Carol, Colledge Danielle, Edwards Rosalind, Ayres Anna, Bartholomeusz Angeline, Locarnini Stephen

Abstract excerpt

BACKGROUND & AIMS: Adefovir dipivoxil effectively inhibits both hepatitis B virus (HBV) replication and disease activity in patients with chronic hepatitis B. Resistance to treatment was not observed in 2 recent large placebo-controlled 48-week studies with this drug. The aim of this study was to characterize adefovir resistance in a patient who developed clinical and virologic evidence of breakthrough during a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12891527
DOI: 10.1016/s0016-5085(03)00939-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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