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The Prostate Cancer-Associated Human Retrovirus XMRV Lacks Direct Transforming Activity but Can Induce Low Rates of Transformation in Cultured Cells

10 Dec 2009

Abstract excerpt

The human retrovirus XMRV (xenotropic murine leukemia virus-related virus) is associated with prostate cancer, but a causal relationship has not been established. Here, we have used cultured fibroblast and epithelial cell lines to test the hypothesis that XMRV might have direct transforming activity but found only rare transformation events, suggestive of indirect transformation, even when the target cells...

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PMID: 20007266
DOI: 10.1128/jvi.01941-09

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Related research

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The Prostate Cancer-Associated Human Retrovirus XMRV Lacks Direct Transforming Activity but Can Induce Low Rates of Transformation in Cultured CellsPMID 20007266Read ↗

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Multiple Integrated Copies and High-Level Production of the Human Retrovirus XMRV (Xenotropic Murine Leukemia Virus-Related Virus) from 22Rv1 Prostate Carcinoma CellsSemantic proximity Read ↗

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In-depth investigation of archival and prospectively collected samples reveals no evidence for XMRV infection in prostate cancer.Semantic proximity Read ↗

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Biology and pathophysiology of the new human retrovirus XMRV and its association with human disease.Semantic proximity Read ↗

Fibrils of Prostatic Acid Phosphatase Fragments Boost Infections with XMRV (Xenotropic Murine Leukemia Virus-Related Virus), a Human Retrovirus Associated with Prostate CancerSemantic proximity Read ↗

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No evidence of XMRV in prostate cancer cohorts in the Midwestern United States.Semantic proximity Read ↗

Absence of XMRV and closely related viruses in primary prostate cancer tissues used to derive the XMRV-infected cell line 22Rv1.Semantic proximity Read ↗

Mouse DNA contamination in human tissue tested for XMRVSemantic proximity Read ↗

Human APOBEC3 proteins can inhibit xenotropic murine leukemia virus-related virus infectivity.Semantic proximity Read ↗

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