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Article

Recombinant Origin of the Retrovirus XMRV

1 Jun 2011

Abstract excerpt

The retrovirus XMRV (xenotropic murine leukemia virus-related virus) has been detected in human prostate tumors and in blood samples from patients with chronic fatigue syndrome, but these findings have not been replicated. We hypothesized that an understanding of when and how XMRV first arose might help explain the discrepant results. We studied human prostate cancer cell lines CWR22Rv1 and CWR-R1, which produce...

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PMID: 21628392
DOI: 10.1126/science.1205292

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Recombinant Origin of the Retrovirus XMRVPMID 21628392Read ↗

Characterization, Mapping, and Distribution of the Two XMRV Parental ProvirusesSemantic proximity Read ↗

In-depth investigation of archival and prospectively collected samples reveals no evidence for XMRV infection in prostate cancer.Semantic proximity Read ↗

Absence of XMRV and closely related viruses in primary prostate cancer tissues used to derive the XMRV-infected cell line 22Rv1.Semantic proximity Read ↗

Disease-associated XMRV sequences are consistent with laboratory contaminationSemantic proximity Read ↗

Multiple Integrated Copies and High-Level Production of the Human Retrovirus XMRV (Xenotropic Murine Leukemia Virus-Related Virus) from 22Rv1 Prostate Carcinoma CellsSemantic proximity Read ↗

Contamination of clinical specimens with MLV-encoding nucleic acids: implications for XMRV and other candidate human retrovirusesSemantic proximity Read ↗

Biology and pathophysiology of the new human retrovirus XMRV and its association with human disease.Semantic proximity Read ↗

The Prostate Cancer-Associated Human Retrovirus XMRV Lacks Direct Transforming Activity but Can Induce Low Rates of Transformation in Cultured CellsSemantic proximity Read ↗

Mouse DNA contamination in human tissue tested for XMRVSemantic proximity Read ↗

Identification of Replication Competent Murine Gammaretroviruses in Commonly Used Prostate Cancer Cell LinesSemantic proximity Read ↗

Contamination of human DNA samples with mouse DNA can lead to false detection of XMRV-like sequencesSemantic proximity Read ↗

Multiple sources of contamination in samples from patients reported to have XMRV infection.Semantic proximity Read ↗

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