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Article

In-depth investigation of archival and prospectively collected samples reveals no evidence for XMRV infection in prostate cancer.

PloS one - 1 Jan 2012

Lee Deanna, Das Gupta Jaydip, Gaughan Christina, Steffen Imke, Tang Ning, Luk Ka-Cheung, Qiu Xiaoxing, Urisman Anatoly, Fischer Nicole, Molinaro Ross, Broz Miranda, Schochetman Gerald, Klein Eric A, Ganem Don, Derisi Joseph L, Simmons Graham, Hackett John, Silverman Robert H, Chiu Charles Y

Abstract excerpt

XMRV, or xenotropic murine leukemia virus (MLV)-related virus, is a novel gammaretrovirus originally identified in studies that analyzed tissue from prostate cancer patients in 2006 and blood from patients with chronic fatigue syndrome (CFS) in 2009. However, a large number of subsequent studies failed to confirm a link between XMRV infection and CFS or prostate cancer. On the contrary, recent evidence indicates...

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Identifiers

PMID: 23028701
DOI: 10.1371/journal.pone.0044954
PMCID: PMC3445615

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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In-depth investigation of archival and prospectively collected samples reveals no evidence for XMRV infection in prostate cancer.PMID 23028701Read ↗

Contamination of clinical specimens with MLV-encoding nucleic acids: implications for XMRV and other candidate human retrovirusesSemantic proximity Read ↗

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Biology and pathophysiology of the new human retrovirus XMRV and its association with human disease.Semantic proximity Read ↗

Mouse DNA contamination in human tissue tested for XMRVSemantic proximity Read ↗

Disease-associated XMRV sequences are consistent with laboratory contaminationSemantic proximity Read ↗

XMRV is present in malignant prostatic epithelium and is associated with prostate cancer, especially high-grade tumors.Semantic proximity Read ↗

XMRV Infection in Patients With Prostate Cancer: Novel Serologic Assay and Correlation With PCR and FISHSemantic proximity Read ↗

Identification of Replication Competent Murine Gammaretroviruses in Commonly Used Prostate Cancer Cell LinesSemantic proximity Read ↗

Contamination of human DNA samples with mouse DNA can lead to false detection of XMRV-like sequencesSemantic proximity Read ↗

No association of xenotropic murine leukemia virus-related viruses with prostate cancer.Semantic proximity Read ↗

Recombinant Origin of the Retrovirus XMRVSemantic proximity Read ↗

Multiple Integrated Copies and High-Level Production of the Human Retrovirus XMRV (Xenotropic Murine Leukemia Virus-Related Virus) from 22Rv1 Prostate Carcinoma CellsSemantic proximity Read ↗

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