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Identification of Replication Competent Murine Gammaretroviruses in Commonly Used Prostate Cancer Cell Lines

17 Jun 2011

Abstract excerpt

A newly discovered gammaretrovirus, termed XMRV, was recently reported to be present in the prostate cancer cell line CWR22Rv1. Using a combination of both immunohistochemistry with broadly-reactive murine leukemia virus (MLV) anti-sera and PCR, we determined if additional prostate cancer or other cell lines contain XMRV or MLV-related viruses. Our study included a total of 72 cell lines, which included 58 of the...

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PMID: 21698104
DOI: 10.1371/journal.pone.0020874

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Identification of Replication Competent Murine Gammaretroviruses in Commonly Used Prostate Cancer Cell LinesPMID 21698104Read ↗

In-depth investigation of archival and prospectively collected samples reveals no evidence for XMRV infection in prostate cancer.Semantic proximity Read ↗

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Multiple Integrated Copies and High-Level Production of the Human Retrovirus XMRV (Xenotropic Murine Leukemia Virus-Related Virus) from 22Rv1 Prostate Carcinoma CellsSemantic proximity Read ↗

Absence of XMRV and closely related viruses in primary prostate cancer tissues used to derive the XMRV-infected cell line 22Rv1.Semantic proximity Read ↗

The Prostate Cancer-Associated Human Retrovirus XMRV Lacks Direct Transforming Activity but Can Induce Low Rates of Transformation in Cultured CellsSemantic proximity Read ↗

No association of xenotropic murine leukemia virus-related viruses with prostate cancer.Semantic proximity Read ↗

Contamination of clinical specimens with MLV-encoding nucleic acids: implications for XMRV and other candidate human retrovirusesSemantic proximity Read ↗

Mouse DNA contamination in human tissue tested for XMRVSemantic proximity Read ↗

Prevalence of human gammaretrovirus XMRV in sporadic prostate cancerSemantic proximity Read ↗

No evidence of XMRV in prostate cancer cohorts in the Midwestern United States.Semantic proximity Read ↗

Biology and pathophysiology of the new human retrovirus XMRV and its association with human disease.Semantic proximity Read ↗

Xenotropic Murine Leukemia Virus–related Gammaretrovirus in Respiratory TractSemantic proximity Read ↗

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