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Article

Human APOBEC3 proteins can inhibit xenotropic murine leukemia virus-related virus infectivity.

Virology - 5 Feb 2011

Bogerd Hal P, Zhang Fengwen, Bieniasz Paul D, Cullen Bryan R

Abstract excerpt

Xenotropic murine leukemia virus-related virus (XMRV) is a novel retrovirus, related to murine leukemia virus (MLV), that has been implicated in human disease. If XMRV is indeed able to replicate in humans, then one might predict that XMRV would have developed resistance to human innate antiviral resistance factors such as APOBEC3G (hA3G). In fact, we observed that XMRV and MLV are both highly sensitive to...

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Identifiers

PMID: 21131013
DOI: 10.1016/j.virol.2010.11.011
PMCID: PMC3035163

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