Article
The C-terminal region of PTHrP, in addition to the nuclear localization signal, is essential for the intracrine stimulation of proliferation in vascular smooth muscle cells.
Endocrinology - 1 Sept 2001
de Miguel F, Fiaschi-Taesch N, López-Talavera J C, Takane K K, Massfelder T, Helwig J J, Stewart A F
Abstract excerpt
PTHrP is secreted by most cell types. In addition to a paracrine/autocrine role, PTHrP has "intracrine" actions, entering the nuclear compartment under the direction of a classic bipartite nuclear localization signal. In vascular smooth muscle cells, nuclear entry stimulates mitogenesis. In the current study, we sought to more precisely define the regions of PTHrP required for the activation of mitogenesis in...
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