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Article

Progressive noradrenergic deficits in the locus coeruleus of Mecp2 deficient mice.

Journal of neuroscience research - 15 May 2010

Roux Jean-Christophe, Panayotis Nicolas, Dura Emmanuelle, Villard Laurent

Abstract excerpt

Methyl-CpG binding protein 2 (MeCP2) is a transcriptional regulator. Mutations in this gene cause a wide range of neurological disorders. Mecp2 deficiency has been previously associated to catecholaminergic dysfunctions leading to autonomic defects in the brainstem and the sympathoadrenergic system of the mouse. The present study was undertaken to determine if the locus coeruleus (LC), the main noradrenergic cell...

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PMID: 19998492
DOI: 10.1002/jnr.22312

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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