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Article

Brain-derived neurotrophic factor is essential for opiate-induced plasticity of noradrenergic neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 May 2002

Akbarian Schahram, Rios Maribel, Liu Rong-Jian, Gold Stephen J, Fong Hiu-Fai, Zeiler Steve, Coppola Vincenzo, Tessarollo Lino, Jones Kevin R, Nestler Eric J, Aghajanian George K, Jaenisch Rudolf

Abstract excerpt

Chronic opiate exposure induces numerous neurochemical adaptations in the noradrenergic system, including upregulation of the cAMP-signaling pathway and increased expression of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis. These adaptations are thought to compensate for opiate-mediated neuronal inhibition but also contribute to physical dependence, including withdrawal after...

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Identifiers

PMID: 12019333
PMCID: PMC6757651

Genes

BDNF
TH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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