Article
Forebrain PENK and PDYN gene expression levels in three inbred strains of mice and their relationship to genotype-dependent morphine reward sensitivity.
Psychopharmacology - 1 Feb 2010
Gieryk Agnieszka, Ziolkowska Barbara, Solecki Wojciech, Kubik Jakub, Przewlocki Ryszard
Abstract excerpt
RATIONALE: Vulnerability to drug abuse disorders is determined not only by environmental but also by genetic factors. A body of evidence suggests that endogenous opioid peptide systems may influence rewarding effects of addictive substances, and thus, their individual expression levels may contribute to drug abuse liability. OBJECTIVES: The aim of our study was to assess whether basal genotype-dependent brain...
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