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Article

Structural requirements for PACSIN/Syndapin operation during zebrafish embryonic notochord development.

PloS one - 3 Dec 2009

Edeling Melissa A, Sanker Subramaniam, Shima Takaki, Umasankar P K, Höning Stefan, Kim Hye Y, Davidson Lance A, Watkins Simon C, Tsang Michael, Owen David J, Traub Linton M

Abstract excerpt

PACSIN/Syndapin proteins are membrane-active scaffolds that participate in endocytosis. The structure of the Drosophila Syndapin N-terminal EFC domain reveals a crescent shaped antiparallel dimer with a high affinity for phosphoinositides and a unique membrane-inserting prong upon the concave surface. Combined structural, biochemical and reverse genetic approaches in zebrafish define an important role for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19997509
DOI: 10.1371/journal.pone.0008150
PMCID: PMC2780292

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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