Article
Interaction of notochord-derived fibrinogen-like protein with Notch regulates the patterning of the central nervous system of Ciona intestinalis embryos.
Developmental biology - 1 Apr 2009
Yamada Shigehiro, Hotta Kohji, Yamamoto Takamasa S, Ueno Naoto, Satoh Nori, Takahashi Hiroki
Abstract excerpt
The midline organ the notochord and its overlying dorsal neural tube are the most prominent features of the chordate body plan. Although the molecular mechanisms involved in the formation of the central nervous system (CNS) have been studied extensively in vertebrate embryos, none of the genes that are expressed exclusively in notochord cells has been shown to function in this process. Here, we report a gene in...
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