Genotypic prediction of HIV-1 CRF01-AE tropism.

doi:10.1128/JCM.02328-12

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Article

Genotypic prediction of HIV-1 CRF01-AE tropism.

Journal of clinical microbiology - 1 Feb 2013

Raymond Stéphanie, Delobel Pierre, Rogez Sylvie, Encinas Stéphanie, Bruel Patrick, Pasquier Christophe, Sandres-Sauné Karine, Marchou Bruno, Massip Patrice, Izopet Jacques

Abstract excerpt

HIV-1 subtype CRF01-AE predominates in south Asia and has spread throughout the world. The virus tropism must be determined before using CCR5 antagonists. Genotypic methods could be used, but the prediction algorithms may be inaccurate for non-B subtypes like CRF01-AE and the correlation with the phenotypic approach has not been assessed. We analyzed 61 CRF01-AE V3 clonal sequences of known phenotype from the...

Topics

Adult
Algorithms
Amino Acid Sequence
Female
Genetic Association Studies
Genotype
HIV Envelope Protein gp120
HIV-1
Humans
Male
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Peptide Fragments

Phenotype

ROC Curve

Receptors, CCR5

Receptors, CXCR4

Sequence Alignment

Viral Tropism

Source

Open in PubMed Open full text

Identifiers

PMID: 23224099
DOI: 10.1128/JCM.02328-12
PMCID: PMC3553889

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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