Statistical tests of genetic association in the presence of gene-gene and gene-environment interactions.

Abstract excerpt

BACKGROUND: While its importance is well recognized, it remains challenging to test genetic association in the presence of gene-gene (or gene-environment) interactions. A major technical difficulty lies in the fact that a general model of gene-gene interactions calls for the use of often a large number of parameters, leading to possibly reduced statistical power. An emerging theme of some recent work is to reduce...

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