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Article

Inhibition of SIRT1 deacetylase suppresses estrogen receptor signaling

8 Dec 2009

Abstract excerpt

Estrogen receptor alpha (ERalpha) mediates estrogen-dependent gene transcription, which plays a critical role in mammary gland development, reproduction and homeostasis. Histone acetyltransferases and class I and class II histone deacetylases (HDACs) cause posttranscriptional modification of histone proteins that participate in ERalpha signaling. Here, we report that human SIRT1, a class III HDAC, regulates...

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PMID: 19995796
DOI: 10.1093/carcin/bgp308

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