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Article

Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity.

Molecular cell - 26 Oct 2007

Kim Eun-Joo, Kho Jeong-Hoon, Kang Moo-Rim, Um Soo-Jong

Abstract excerpt

Human SIRT1 is an NAD+-dependent deacetylase protein that plays a role in cell death/survival, senescence, and endocrine signaling. While its substrates, including p53, have been well characterized, no direct regulators are known. We describe here a nuclear protein, active regulator of SIRT1 (AROS), which directly regulates SIRT1 function. AROS enhanced SIRT1-mediated deacetylation of p53 both in vitro and in...

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Source

Identifiers

PMID: 17964266
DOI: 10.1016/j.molcel.2007.08.030

Genes

SIRT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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