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Article

Hormonal Control of Androgen Receptor Function through SIRT1

18 Oct 2006

Abstract excerpt

The NAD-dependent histone deacetylase Sir2 plays a key role in connecting cellular metabolism with gene silencing and aging. The androgen receptor (AR) is a ligand-regulated modular nuclear receptor governing prostate cancer cellular proliferation, differentiation, and apoptosis in response to androgens, including dihydrotestosterone (DHT). Here, SIRT1 antagonists induce endogenous AR expression and enhance...

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Identifiers

PMID: 16923962
DOI: 10.1128/mcb.00289-06

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