Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sirtuin 1 Is Required for Antagonist-Induced Transcriptional Repression of Androgen-Responsive Genes by the Androgen Receptor

16 May 2007

Abstract excerpt

Androgen antagonists or androgen deprivation is a primary therapeutic modality for the treatment of prostate cancer. Invariably, however, the disease becomes progressive and unresponsive to androgen ablation therapy (hormone refractory). The molecular mechanisms by which the androgen antagonists inhibit prostate cancer proliferation are not fully defined. In this report, we demonstrate that sirtuin 1 (SIRT1), a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to PARP inhibition in cancer therapy
Share to Prostate Cancer Treatment and Research
Share to Sirtuins and Resveratrol in Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17505061
DOI: 10.1210/me.2006-0467

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sirtuin 1 Is Required for Antagonist-Induced Transcriptional Repression of Androgen-Responsive Genes by the Androgen ReceptorPMID 17505061Read ↗

Hormonal Control of Androgen Receptor Function through SIRT1Semantic proximity Read ↗

Androgen deprivation-induced elevated nuclear SIRT1 promotes prostate tumor cell survival by reactivation of AR signalingSemantic proximity Read ↗

Histone Deacetylases Are Required for Androgen Receptor Function in Hormone-Sensitive and Castrate-Resistant Prostate CancerSemantic proximity Read ↗

Role of Sirtuin Histone Deacetylase SIRT1 in Prostate CancerSemantic proximity Read ↗

Molecular Sentinels: Unveiling the Role of Sirtuins in Prostate Cancer ProgressionSemantic proximity Read ↗

Inhibition of SIRT1 deacetylase suppresses estrogen receptor signalingSemantic proximity Read ↗

Molecular Sentinels: Unveiling the Role of Sirtuins in Prostate Cancer ProgressionSemantic proximity Read ↗

Prohibitin and the SWI/SNF ATPase subunit BRG1 are required for effective androgen antagonist-mediated transcriptional repression of androgen receptor-regulated genesSemantic proximity Read ↗

miR-449a targets HDAC-1 and induces growth arrest in prostate cancer.Semantic proximity Read ↗

SIRT1 negatively regulates HDAC1-dependent transcriptional repression by the RBP1 family of proteinsSemantic proximity Read ↗

Sirtuin 5 regulates the proliferation, invasion and migration of prostate cancer cells through acetyl‐CoA acetyltransferase 1Semantic proximity Read ↗

Inactivation of androgen-induced regulator ARD1 inhibits androgen receptor acetylation and prostate tumorigenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.